Carbon Monoxide Promotes VEGF Expression by Increasing HIF-1α Protein Level via Two Distinct Mechanisms, Translational Activation and Stabilization of HIF-1α Protein

Carbon monoxide (CO) plays a significant role in vascular functions. We here examined the molecular mechanism by which CO regulates HIF-1 (hypoxia-inducible transcription factor-1)-dependent expression of vascular endothelial growth factor (VEGF), which is an important angiogenic factor. We found th...

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Detalhes bibliográficos
Main Authors: Choi, Yoon Kyung, Kim, Chun-Ki, Lee, Hansoo, Jeoung, Dooil, Ha, Kwon-Soo, Kwon, Young-Guen, Kim, Kyu-Won, Kim, Young-Myeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952213/
https://ncbi.nlm.nih.gov/pubmed/20724477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131284
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