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Hyaluronan Synthesis Mediates the Fibrotic Response of Keratocytes to Transforming Growth Factor β
TGFβ induces fibrosis in healing corneal wounds, and in vitro corneal keratocytes up-regulate expression of several fibrosis-related genes in response to TGFβ. Hyaluronan (HA) accumulates in healing corneas, and HA synthesis is induced by TGFβ by up-regulation of HA synthase 2. This study tested the...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952202/ https://ncbi.nlm.nih.gov/pubmed/20685654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127183 |
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