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Amide Conjugates of Ketoprofen and Indole as Inhibitors of Gli1-Mediated Transcription in the Hedgehog Pathway
We have previously reported small-molecule inhibitors of Gli1-mediated transcription, an essential down-stream element of the Hh pathway. We created new derivatives of the previous compounds aiming to improve the druggable property. The new compounds, amide conjugates of ketoprofen and indole, showe...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952073/ https://ncbi.nlm.nih.gov/pubmed/20605720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.001 |
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