Temozolomide Delivery to Tumor Cells by a Multifunctional Nano Vehicle Based on Poly(β-L-malic acid)

PURPOSE: Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus needed to improve efficiency and reduce n...

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Hlavní autoři: Patil, Rameshwar, Portilla-Arias, José, Ding, Hui, Inoue, Satoshi, Konda, Bindu, Hu, Jinwei, Wawrowsky, Kolja A., Shin, Paul K., Black, Keith L., Holler, Eggehard, Ljubimova, Julia Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952070/
https://ncbi.nlm.nih.gov/pubmed/20387095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0091-0
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