Cellular Delivery of Doxorubicin via pH-Controlled Hydrazone Linkage Using Multifunctional Nano Vehicle Based on Poly(β-L-Malic Acid)

Doxorubicin (DOX) is currently used in cancer chemotherapy to treat many tumors and shows improved delivery, reduced toxicity and higher treatment efficacy when being part of nanoscale delivery systems. However, a major drawback remains its toxicity to healthy tissue and the development of multi-dru...

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Detalhes bibliográficos
Main Authors: Patil, Rameshwar, Portilla-Arias, Jose, Ding, Hui, Konda, Bindu, Rekechenetskiy, Arthur, Inoue, Satoshi, Black, Keith L., Holler, Eggehard, Ljubimova, Julia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472769/
https://ncbi.nlm.nih.gov/pubmed/23109877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms130911681
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