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DR1001 presents ‘altered-self’ peptides derived from joint associated proteins by accepting citrulline in three of its binding pockets
OBJECTIVE: HLA-DRB1*1001 (DR1001) is a shared epitope allele associated with rheumatoid arthritis. The objectives of this study were to assess the capacity of DR1001 to accommodate citrulline in its binding pockets and to identify citrullinated T cell epitopes derived from joint associated proteins....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952065/ https://ncbi.nlm.nih.gov/pubmed/20533291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27594 |
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