Staphylococcal Peptidoglycan Co-Localizes with Nod2 and TLR2 and Activates Innate Immune Response via Both Receptors in Primary Murine Keratinocytes

In mammalian host cells staphylococcal peptidoglycan (PGN) is recognized by Nod2. Whether PGN is also recognized by TLR2 is disputed. Here we carried out PGN co-localization and stimulation studies with TLR2 and Nod2 in wild type and mutant host cells. To exclude contamination with lipoproteins, pol...

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Detalhes bibliográficos
Main Authors: Müller-Anstett, Maria Anna, Müller, Patrick, Albrecht, Till, Nega, Mulugeta, Wagener, Jeanette, Gao, Qiang, Kaesler, Susanne, Schaller, Martin, Biedermann, Tilo, Götz, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951902/
https://ncbi.nlm.nih.gov/pubmed/20949035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013153
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