SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy

Reduced expression of the survival motor neuron (SMN) gene causes the childhood motor neuron disease spinal muscular atrophy (SMA). Low levels of ubiquitously expressed SMN protein result in the degeneration of lower motor neurons, but it remains unclear whether other regions of the nervous system a...

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Autores principales: Wishart, Thomas M., Huang, Jack P.-W., Murray, Lyndsay M., Lamont, Douglas J., Mutsaers, Chantal A., Ross, Jenny, Geldsetzer, Pascal, Ansorge, Olaf, Talbot, Kevin, Parson, Simon H., Gillingwater, Thomas H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951867/
https://ncbi.nlm.nih.gov/pubmed/20705736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq340
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