Lower Succinyl-CoA:3-ketoacid-CoA Transferase (SCOT) and ATP Citrate Lyase In Pancreatic Islets of A Rat Model of Type 2 Diabetes: Knockdown of SCOT Inhibits Insulin Release In Rat Insulinoma Cells

Succinyl-CoA:3-ketoacid-CoA transferase (SCOT) is a mitochondrial enzyme that catalyzes the reversible transfer of coenzyme-A from acetoacetyl-CoA to succinate to form acetoacetate and succinyl-CoA. mRNAs of SCOT and ATP citrate lyase were decreased 55% and 58% and enzyme activities were decreased &...

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Autori principali: Hasan, Noaman M., Longacre, Melissa J., Seed Ahmed, Mohammed, Kendrick, Mindy A., Gu, Harvest, Ostenson, Claes-Goran, Fukao, Toshiyuki, MacDonald, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951839/
https://ncbi.nlm.nih.gov/pubmed/20460097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.05.007
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