Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors

We have performed molecular docking on quinazoline antifolates complexed with human thymidylate synthase to gain insight into the structural preferences of these inhibitors. The study was conducted on a selected set of one hundred six compounds with variation in structure and activity. The structura...

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Bibliographic Details
Main Authors: Srivastava, Vivek, Gupta, Satya Prakash, Siddiqi, Mohd. Imran, Mishra, Bhartendu Nath
Format: Artigo
Language:Inglês
Published: Biomedical Informatics Publishing Group 2010
Subjects:
Hypothesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951674/
https://ncbi.nlm.nih.gov/pubmed/20975900
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