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The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease

Red blood cells from patients with sickle cell disease (SCD) exhibit increased electrogenic cation permeability, particularly following deoxygenation and hemoglobin (Hb) polymerisation. This cation permeability, termed P(sickle), contributes to cellular dehydration and sickling, and its inhibition r...

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Detaylı Bibliyografya
Asıl Yazarlar: Browning, Joseph A., Staines, Henry M., Robinson, Hannah C., Powell, Trevor, Ellory, J. Clive, Gibson, John S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951509/
https://ncbi.nlm.nih.gov/pubmed/17138828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-001404
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