PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited time window of efficacy, indicating a need for additional therapeutic options. Zebrafish have emerged as a powerful too...

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Detalhes bibliográficos
Main Authors: North, Trista E., Babu, I. Ramesh, Vedder, Lea M., Lord, Allegra M., Wishnok, John S., Tannenbaum, Steven R., Zon, Leonard I., Goessling, Wolfram
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951415/
https://ncbi.nlm.nih.gov/pubmed/20855591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008209107
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