Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

Neurons rely on their metabolic coupling with astrocytes to combat oxidative stress. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) appears important for astrocyte-dependent neuroprotection from oxidative insults. Indeed, Nrf2 activators are effective in stroke, Parkinso...

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Detalhes bibliográficos
Main Authors: Haskew-Layton, Renée E., Payappilly, Jimmy B., Smirnova, Natalya A., Ma, Thong C., Chan, Kelvin K., Murphy, Timothy H., Guo, Hengchang, Langley, Brett, Sultana, Rukhsana, Butterfield, D. Allan, Santagata, Sandro, Alldred, Melissa J., Gazaryan, Irina G., Bell, George W., Ginsberg, Stephen D., Ratan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951414/
https://ncbi.nlm.nih.gov/pubmed/20855618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003996107
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