Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

Neurons rely on their metabolic coupling with astrocytes to combat oxidative stress. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) appears important for astrocyte-dependent neuroprotection from oxidative insults. Indeed, Nrf2 activators are effective in stroke, Parkinso...

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Main Authors: Haskew-Layton, Renée E., Payappilly, Jimmy B., Smirnova, Natalya A., Ma, Thong C., Chan, Kelvin K., Murphy, Timothy H., Guo, Hengchang, Langley, Brett, Sultana, Rukhsana, Butterfield, D. Allan, Santagata, Sandro, Alldred, Melissa J., Gazaryan, Irina G., Bell, George W., Ginsberg, Stephen D., Ratan, Rajiv R.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951414/
https://ncbi.nlm.nih.gov/pubmed/20855618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003996107
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