Glycosylation of β2 Subunits Regulates GABA(A) Receptor Biogenesis and Channel Gating

γ-Aminobutyric acid type A (GABA(A)) receptors are heteropentameric glycoproteins. Based on consensus sequences, the GABA(A) receptor β2 subunit contains three potential N-linked glycosylation sites, Asn-32, Asn-104, and Asn-173. Homology modeling indicates that Asn-32 and Asn-104 are located before...

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Main Authors: Lo, Wen-yi, Lagrange, Andre H., Hernandez, Ciria C., Harrison, Rebecca, Dell, Anne, Haslam, Stuart M., Sheehan, Jonathan H., Macdonald, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951209/
https://ncbi.nlm.nih.gov/pubmed/20639197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151449
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