Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation

AKT phosphorylates components of the intrinsic cell survival machinery and promotes survival to various stimuli. In the present study, we identified CDC-like kinase 2 (CLK2) as a new substrate of AKT activation and elucidated its role in cell survival to ionizing radiation. AKT directly binds to and...

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Detalhes bibliográficos
Main Authors: Nam, Seon Young, Seo, Hyung Ho, Park, Hyung Sun, An, Sungkwan, Kim, Ji-Young, Yang, Kwang Hee, Kim, Cha Soon, Jeong, Meeseon, Jin, Young-Woo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951189/
https://ncbi.nlm.nih.gov/pubmed/20682768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122044
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