Phosphorylation of CLK2 at Serine 34 and Threonine 127 by AKT Controls Cell Survival after Ionizing Radiation

AKT phosphorylates components of the intrinsic cell survival machinery and promotes survival to various stimuli. In the present study, we identified CDC-like kinase 2 (CLK2) as a new substrate of AKT activation and elucidated its role in cell survival to ionizing radiation. AKT directly binds to and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nam, Seon Young, Seo, Hyung Ho, Park, Hyung Sun, An, Sungkwan, Kim, Ji-Young, Yang, Kwang Hee, Kim, Cha Soon, Jeong, Meeseon, Jin, Young-Woo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951189/
https://ncbi.nlm.nih.gov/pubmed/20682768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.122044
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