Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

Ca(2+) is an essential and ubiquitous second messenger. Changes in cytosolic Ca(2+) trigger events critical for tumorigenesis, such as cellular motility, proliferation and apoptosis. We show that an isoform of Secretory Pathway Ca(2+)-ATPase, SPCA2, is upregulated in breast cancer-derived cells and...

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Detalhes bibliográficos
Main Authors: Feng, Mingye, Grice, Desma M., Faddy, Helen M., Nguyen, Nguyen, Leitch, Sharon, Wang, Yingyu, Muend, Sabina, Kenny, Paraic A., Sukumar, Saraswati, Roberts-Thomson, Sarah J., Monteith, Gregory R., Rao, Rajini
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950964/
https://ncbi.nlm.nih.gov/pubmed/20887894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.08.040
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