Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

Isolated hepatocytes incubated with [35S]-methionine were examined for the time-dependent accumulation of [35S]-glutathione (GSH) in cytosol and mitochondria, the latter confirmed by density gradient purification. In GSH-depleted and -repleted hepatocytes, the increase of specific activity of mitoch...

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Pubblicato in:	J Clin Invest
Autori principali:	Fernández-Checa, J C, García-Ruiz, C, Ookhtens, M, Kaplowitz, N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1991826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115010
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