Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

Isolated hepatocytes incubated with [35S]-methionine were examined for the time-dependent accumulation of [35S]-glutathione (GSH) in cytosol and mitochondria, the latter confirmed by density gradient purification. In GSH-depleted and -repleted hepatocytes, the increase of specific activity of mitoch...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Fernández-Checa, J C, García-Ruiz, C, Ookhtens, M, Kaplowitz, N
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295090/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1991826/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115010
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