A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum

A natural BH3-mimetic, small-molecule inhibitor of Bcl-2, (−)-gossypol, shows promise in ongoing phase II and III clinical trials for human prostate cancer. In this study we show that (−)-gossypol preferentially induces autophagy in androgen-independent (AI) prostate cancer cells that have high leve...

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Bibliografiske detaljer
Main Authors: Lian, J, Wu, X, He, F, Karnak, D, Tang, W, Meng, Y, Xiang, D, Ji, M, Lawrence, T S, Xu, L
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950895/
https://ncbi.nlm.nih.gov/pubmed/20577262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.74
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