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MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites

Sporadic mutations in the hMeCP2 gene, coding for a protein that preferentially binds symmetrically methylated CpGs, result in the severe neurological disorder Rett syndrome (RTT). In the present work, employing a wide range of experimental approaches, we shed new light on the many levels of MeCP2 i...

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Autors principals: Ghosh, Rajarshi P., Horowitz-Scherer, Rachel A., Nikitina, Tatiana, Shlyakhtenko, Luda S., Woodcock, Christopher L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950531/
https://ncbi.nlm.nih.gov/pubmed/20679481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00379-10
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