Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.

The melanoma cell line FO-1 does not express HLA class I antigens and does not acquire them on the cell surface after incubation with IFN-gamma. Immunochemical studies showed that FO-1 cells synthesize HLA class I heavy chain, but do not synthesize beta 2-microglobulin (beta 2-mu). The latter abnorm...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: D'Urso, C M, Wang, Z G, Cao, Y, Tatake, R, Zeff, R A, Ferrone, S
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295046/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1898655/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114984
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