Survival Defects of Cryptococcus neoformans Mutants Exposed to Human Cerebrospinal Fluid Result in Attenuated Virulence in an Experimental Model of Meningitis

Cryptococcus neoformans is a fungal pathogen that encounters various microenvironments during growth in the mammalian host, including intracellular vacuoles, blood, and cerebrospinal fluid (CSF). Because the CSF is isolated by the blood-brain barrier, we hypothesize that CSF presents unique stresses...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Anthony, Toffaletti, Dena L., Tenor, Jennifer, Soderblom, Erik J., Thompson, J. Will, Moseley, M. Arthur, Price, Michael, Perfect, John R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950369/
https://ncbi.nlm.nih.gov/pubmed/20696827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00551-10
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