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Developmental Expression of a Trypanosoma cruzi Phosphoinositide-Specific Phospholipase C in Amastigotes and Stimulation of Host Phosphoinositide Hydrolysis

Phosphoinositide phospholipase C (PI-PLC) plays an essential role in cell signaling. A unique Trypanosoma cruzi PI-PLC (TcPI-PLC) is lipid modified in its N terminus and localizes to the outer surface of the plasma membrane of amastigotes. We show here that TcPI-PLC is developmentally regulated in a...

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Main Authors: de Paulo Martins, Vicente, Galizzi, Melina, Salto, Maria Laura, Docampo, Roberto, Moreno, Silvia N. J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950344/
https://ncbi.nlm.nih.gov/pubmed/20643853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00473-10
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