Endoplasmic Reticulum Calcium Regulates the Retrotranslocation of Trypanosoma Cruzi Calreticulin to the Cytosol

For most secretory pathway proteins, crossing the endoplasmic reticulum (ER) membrane is an irreversible process. However, in some cases this flow can be reversed. For instance, misfolded proteins retained in the ER are retrotranslocated to the cytosol to be degraded by the proteasome. This mechanis...

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Bibliographic Details
Main Authors: Labriola, Carlos A., Conte, Ianina L., López Medus, Máximo, Parodi, Armando J., Caramelo, Julio J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950133/
https://ncbi.nlm.nih.gov/pubmed/20957192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013141
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