Endothelin action in rat liver. Receptors, free Ca2+ oscillations, and activation of glycogenolysis.

High affinity binding sites for endothelin (ET) were identified on rat liver plasma membranes. Binding of 125I-ET-1 with its site was specific, saturable, and time dependent (kobs = 0.019 +/- 0.001 min-1), but dissociation of receptor-bound ligand was minimal. A single class of high affinity binding...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Serradeil-Le Gal, C, Jouneaux, C, Sanchez-Bueno, A, Raufaste, D, Roche, B, Préaux, A M, Maffrand, J P, Cobbold, P H, Hanoune, J, Lotersztajn, S
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1991
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1845867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114962
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