Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia.

To explore our hypothesis of a direct reticulocyte origin of irreversibly sickled cells (ISCs), we fractionated light, reticulocyte-rich, and discocyte-rich sickle anemia red cells on Stractan gradients, and examined the effects of deoxygenation-induced sickling, external Ca2+, acidification, and re...

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Pubblicato in:	J Clin Invest
Autori principali:	Bookchin, R M, Ortiz, O E, Lew, V L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295004/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1702096/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114959
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