Evidence for a direct reticulocyte origin of dense red cells in sickle cell anemia.

To explore our hypothesis of a direct reticulocyte origin of irreversibly sickled cells (ISCs), we fractionated light, reticulocyte-rich, and discocyte-rich sickle anemia red cells on Stractan gradients, and examined the effects of deoxygenation-induced sickling, external Ca2+, acidification, and re...

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Bibliographic Details
Main Authors: Bookchin, R M, Ortiz, O E, Lew, V L
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC295004/
https://ncbi.nlm.nih.gov/pubmed/1702096
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