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The IL Sequence in the LLKIL Motif in CXCR2 Is Required for Full Ligand-induced Activation of Erk, Akt, and Chemotaxis in HL60 Cells

The chemotaxis of differentiated HL60 cells stably expressing CXCR2 was examined in a microfluidic gradient device where the steepness of the CXCL8 chemokine gradient was varied from 2 pg/ml/μm (0–1 ng/ml over a width of 500 μm) to 50 pg/ml/μm (0–25 ng/ml over 500 μm). The differentiated HL60 cells...

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Autors principals: Sai, Jiqing, Walker, Glenn, Wikswo, John, Richmond, Ann
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950015/
https://ncbi.nlm.nih.gov/pubmed/16990258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M605883200
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