Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway

BACKGROUND: Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse...

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Autori principali: Kidera, Yasuhiro, Tsubaki, Masanobu, Yamazoe, Yuzuru, Shoji, Kaori, Nakamura, Haruyuki, Ogaki, Mitsuhiko, Satou, Takao, Itoh, Tatsuki, Isozaki, Misako, Kaneko, Junichi, Tanimori, Yoshihiro, Yanae, Masashi, Nishida, Shozo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949822/
https://ncbi.nlm.nih.gov/pubmed/20843370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-29-127
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