Phosphatidylinositol-3-kinase p110γ Contributes to Bile Salt-Induced Apoptosis in Primary Rat Hepatocytes and Human Hepatoma Cells

BACKGROUND & AIMS: Glycochenodeoxycholate (GCDC) and taurolithocholate (TLC) are hepatotoxic and cholestatic bile salts, whereas tauroursodeoxycholate (TUDC) is cytoprotective and anticholestatic. Yet they all act, in part, through phosphatidylinositol-3-kinase(PI3K)-dependent mechanisms (“PI3K-...

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Autori principali: Hohenester, Simon, Gates, Anna, Wimmer, Ralf, Beuers, Ulrich, Anwer, M. Sawkat, Rust, Christian, Webster, Cynthia R.L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949543/
https://ncbi.nlm.nih.gov/pubmed/20675006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.05.015
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