Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood–brain barrier

We attempted to assess regional differences in cerebral P-glycoprotein (P-gp) function by performing paired positron emission tomography (PET) scans with the P-gp substrate (R)-[(11)C]verapamil in five healthy subjects before and after i.v. infusion of tariquidar (2 mg/kg). Comparison of tariquidar-...

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Dettagli Bibliografici
Autori principali: Bauer, Martin, Karch, Rudolf, Neumann, Friederike, Wagner, Claudia C, Kletter, Kurt, Müller, Markus, Löscher, Wolfgang, Zeitlinger, Markus, Langer, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949150/
https://ncbi.nlm.nih.gov/pubmed/20010957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2009.265
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