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Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia

Heme oxygenase-1 may exert cytoprotective effects. In this study we examined the sensitivity of heme oxygenase-1 knockout (HO-1(−/−)) mice to renal ischemia by assessing glomerular filtration rate (GFR) and cytokine expression in the kidney, and inflammatory responses in the systemic circulation and...

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Detalhes bibliográficos
Main Authors: Tracz, MJ, Juncos, JP, Croatt, AJ, Ackerman, AW, Grande, JP, Knutson, KL, Kane, GC, Terzic, A, Griffin, MD, Nath, KA
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948968/
https://ncbi.nlm.nih.gov/pubmed/17728706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.ki.5002471
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