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Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
In obesity and the early stages of type 2 diabetes (T2D), pro-inflammatory cytokines are mildly elevated in the systemic circulation. This low-grade systemic inflammation exposes pancreatic islets to these circulating cytokines, but at levels ~100–1000x lower than seen within the islet during insuli...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948622/ https://ncbi.nlm.nih.gov/pubmed/20800281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2010.07.007 |
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