Activation of MDM2 by Akt in Mammary Epithelium Delays Mammary Involution and Accelerates Mammary Tumorigenesis

Amplification or overexpression of MDM2 promotes a variety of human tumors by degrading tumor suppressor proteins such as p53. Phosphorylation of MDM2 on serines 166 and 186 by the survival kinase Akt inhibits p53-mediated apoptosis. However, it is unclear whether this pathway contributes to normal...

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Main Authors: Cheng, Xiaoyun, Xia, Weiya, Yang, Jer-Yen, Hsu, Jennifer L., Lang, Jing-Yu, Chou, Chao-Kai, Du, Yi, Sun, Hui-Lung, Wyszomierski, Shannon L., Mills, Gordon B., Muller, William J., Yu, Dihua, Hung, Mien-Chie
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948588/
https://ncbi.nlm.nih.gov/pubmed/20841468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3231
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