Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: A therapeutic strategy based on modulation of mixed lineage kinase

Work from our laboratories has validated mixed lineage kinase type 3 (MLK3) as an enzyme pathologically activated in the CNS by human immunodeficiency virus 1 (HIV-1) neurotoxins. In this review, we discuss MLK3 activation in the context of the neuropathogenesis of HIV-1 associated neurocognitive de...

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Main Authors: Gelbard, Harris A., Dewhurst, Stephen, Maggirwar, Sanjay B., Kiebala, Michelle, Polesskaya, Oksana, Gendelman, Howard E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer-Verlag 2010
Ábhair:
Review Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948545/
https://ncbi.nlm.nih.gov/pubmed/20880503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nurt.2010.08.001
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