Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing

Physical cues, such as extracellular matrix stiffness, direct cell differentiation and support tissue-specific function. Perturbation of these cues underlies diverse pathologies, including osteoarthritis, cardiovascular disease and cancer. However, the molecular mechanisms that establish tissue-spec...

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Dades bibliogràfiques
Autors principals: Chang, Jolie L, Brauer, Delia S, Johnson, Jacob, Chen, Carol G, Akil, Omar, Balooch, Guive, Humphrey, Mary Beth, Chin, Emily N, Porter, Alexandra E, Butcher, Kristin, Ritchie, Robert O, Schneider, Richard A, Lalwani, Anil, Derynck, Rik, Marshall, Grayson W, Marshall, Sally J, Lustig, Lawrence, Alliston, Tamara
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948188/
https://ncbi.nlm.nih.gov/pubmed/20847738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.135
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