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CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia
Here, we report that primary leukemic cells from infants with newly diagnosed B-precursor leukemia express a truncated and functionally defective CD22 coreceptor protein that is unable to transmit apoptotic signals because it lacks most of the intracellular domain, including the key regulatory signa...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947921/ https://ncbi.nlm.nih.gov/pubmed/20841423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007896107 |
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