Establishment of HIV-1 latency in resting CD4(+) T cells depends on chemokine-induced changes in the actin cytoskeleton

Eradication of HIV-1 with highly active antiretroviral therapy (HAART) is not possible due to the persistence of long-lived, latently infected resting memory CD4(+) T cells. We now show that HIV-1 latency can be established in resting CD4(+) T cells infected with HIV-1 after exposure to ligands for...

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Main Authors: Cameron, Paul U., Saleh, Suha, Sallmann, Georgina, Solomon, Ajantha, Wightman, Fiona, Evans, Vanessa A., Boucher, Genevieve, Haddad, Elias K., Sekaly, Rafick-Pierre, Harman, Andrew N., Anderson, Jenny L., Jones, Kate L., Mak, Johnson, Cunningham, Anthony L., Jaworowski, Anthony, Lewin, Sharon R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947912/
https://ncbi.nlm.nih.gov/pubmed/20837531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002894107
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