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Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages
To study the influence of a locus control region (LCR) on the expression of a highly characterized, developmentally regulated locus, we have targeted the hCD2-LCR as a single copy into the endogenous mouse CD8 gene complex. Two knock-in mouse lines that differ in the integration site of the hCD2-LCR...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947902/ https://ncbi.nlm.nih.gov/pubmed/20837519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010317107 |
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