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5′–3′-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage
Optimal induction of p53 protein after DNA damage requires RPL26-mediated increases in p53 mRNA translation. We report here the existence of a dsRNA region containing complementary sequences of the 5′- and 3′-untranslated regions (UTRs) of human p53 mRNA that is critical for its translational regula...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2947767/ https://ncbi.nlm.nih.gov/pubmed/20837656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1968910 |
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