Mice with Inactivation of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Display Complete Penetrance of Pituitary Adenomas with Aberrant ARNT Expression

Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been shown to predispose to pituitary adenoma predisposition, a condition characterized by growth hormone (GH)-secreting pituitary tumors. To study AIP-mediated tumorigenesis, we generated an Aip mouse model. Heterozygous...

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Detalhes bibliográficos
Main Authors: Raitila, Anniina, Lehtonen, Heli J., Arola, Johanna, Heliövaara, Elina, Ahlsten, Manuel, Georgitsi, Marianthi, Jalanko, Anu, Paetau, Anders, Aaltonen, Lauri A., Karhu, Auli
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
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Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947291/
https://ncbi.nlm.nih.gov/pubmed/20709796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100138
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