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Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

Lipopolysaccharide (LPS) preconditioning provides neuroprotection against subsequent cerebral ischemic injury through activation of its receptor, Toll-like receptor 4 (TLR4). Paradoxically, TLR activation by endogenous ligands after ischemia worsens stroke damage. Here, we define a novel, protective...

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Detalhes bibliográficos
Main Authors: Marsh, Brenda, Stevens, Susan L., Packard, Amy E. B., Gopalan, Banu, Hunter, Brian, Leung, Philberta Y., Harrington, Christina A., Stenzel-Poore, Mary P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946887/
https://ncbi.nlm.nih.gov/pubmed/19657036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2496-09.2009
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