Contribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,

[Image: see text] Factor Va, the cofactor of prothrombinase, is composed of heavy and light chains associated noncovalently in the presence of divalent metal ions. The COOH-terminal region of the heavy chain contains acidic amino acid clusters that are important for cofactor activity. In this work,...

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Bibliographic Details
Main Authors: Hirbawi, Jamila, Vaughn, John L., Bukys, Michael A., Vos, Hans L., Kalafatis, Michael
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946813/
https://ncbi.nlm.nih.gov/pubmed/20722419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101097t
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