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Role of the Acidic Hirudin-like COOH-Terminal Amino Acid Region of Factor Va Heavy Chain in the Enhanced Function of Prothrombinase‡
[Image: see text] Prothrombinase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271). This pathway is characterized by the generation of an enzymatically active, transient intermediate, meizothrombin, that has increased chromogenic substrate activity but poor...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646660/ https://ncbi.nlm.nih.gov/pubmed/18590276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800593k |
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