Contribution of Amino Acid Region 334−335 from Factor Va Heavy Chain to the Catalytic Efficiency of Prothrombinase

[Image: see text] We have demonstrated that amino acids E(323), Y(324), E(330), and V(331) from the factor Va heavy chain are required for the interaction of the cofactor with factor Xa and optimum rates of prothrombin cleavage. We have also shown that amino acid region 332−336 contains residues tha...

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Bibliographic Details
Main Authors: Barhoover, Melissa A., Orban, Tivadar, Beck, Daniel O., Bukys, Michael A., Kalafatis, Michael
Format: Artigo
Language:Inglês
Published: American Chemical Society 2008
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652359/
https://ncbi.nlm.nih.gov/pubmed/18537263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800057r
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