Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain

PMD (Pelizaeus–Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Transgenic mice with increased Plp1 [proteolipid protei...

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Bibliografische gegevens
Hoofdauteurs: Tatar, Carrie L, Appikatla, Sunita, Bessert, Denise A, Paintlia, Ajaib S, Singh, Inderjit, Skoff, Robert P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Neurochemistry 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946597/
https://ncbi.nlm.nih.gov/pubmed/20885931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100016
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