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Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain
PMD (Pelizaeus–Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Transgenic mice with increased Plp1 [proteolipid protei...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Neurochemistry
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946597/ https://ncbi.nlm.nih.gov/pubmed/20885931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20100016 |
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