Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.

We produced transgenic mice which overexpress human IL-6 in the airway epithelial cells. Transgenic mice develop a mononuclear cell infiltrate adjacent to large and mid-sized airways. Immunohistochemistry reveals these cells to be predominantly CD4+ cells, MHC class II+ cells, and B220+ cells. Trans...

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Publicat a:J Clin Invest
Autors principals: DiCosmo, B F, Geba, G P, Picarella, D, Elias, J A, Rankin, J A, Stripp, B R, Whitsett, J A, Flavell, R A
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294635/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7962549/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117556
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