α(2)-Adrenergic receptor blockade potentiates the effect of duloxetine, a serotonin and norepinephrine reuptake inhibitor, on sneeze-induced urethral continence reflex in rats

PURPOSE: Serotonin and norepinephrine reuptake inhibitors (SNRI) such as duloxetine have demonstrated clinical efficacy in the treatment of stress urinary incontinence (SUI). However, the therapeutic dose of duloxetine is often associated with unwanted side effects. In the present study, we examined...

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Autori principali: Kitta, Takeya, Miyazato, Minoru, Chancellor, Michael B., de Groat, William C., Nonomura, Katsuya, Yoshimura, Naoki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946347/
https://ncbi.nlm.nih.gov/pubmed/20639053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2010.03.106
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